Symptoms vary. For example in severe loss of
cognitive function, symptoms may include difficulty thinking/concentrating, a
drop in IQ, episodic memory loss, episodic memory gaps, amnesia, spells of
aphasia, episodic problems with confusion, problems with fine/gross motor
coordination, or brief dramatic changes in emotional status. Memory gaps and
other cognitive problems may interfere severely with activities of daily living,
such as working, or safe operation of motor vehicles.
Use of the the Mini-Mental
Status Examination (MMSE) and the digit symbol substitution test: There are
numerous tests that assess mental processing, intellectual functioning,
cognitive ability, and memory. The simplest and most widely used test for
diagnosis of memory loss or cognitive impairment is the modified mini-mental
state exam and the digit symbol substitution test. These tests help assess
short- and long-term memory, spatial abilities, mental processing speed and
many other related cognitive abilities. The testing includes having patients
recall their date and country of birth, to count from 1 to 5 and then backwards
again, to name specific body parts such as an arm or leg, to identify an animal
that has four legs, to recognize associations between similar objects and
activities, to recall objects that were shown previously, and to follow simple
directions, such as folding a piece of paper in half.